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Sep 25 - Sep 27
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Oct 2 - Oct 4

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Our top choices for Isle of Palms South hotels

Lobby

1. Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic

Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic
2.5 star property
1.8 mi from Isle of Palms South
9.0 out of 10, Wonderful, (1,001 reviews)
"Great place to stay."
United States
Patsy
$109 nightly
The price is $124
Oct 4 - Oct 5
Total with taxes and fees
Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic
Terrace/patio

2. Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches

Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches
3.0 star property
0.9 mi from Isle of Palms South
8.4 out of 10, Very good, (797 reviews)
"The staff was very helpful and the parking easy and, in parts, quite shady. It was within easy walking distance of the Mayo Clinic!"
United States
Patricia
$152 nightly
The price is $173
Sep 26 - Sep 27
Total with taxes and fees
Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches
Lobby sitting area

3. Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
2.5 star property
2.3 mi from Isle of Palms South
9.0 out of 10, Wonderful, (1,004 reviews)
"wonderful breakfast and friendly staff"
United States
frances
$101 nightly
The price is $115
Oct 4 - Oct 5
Total with taxes and fees
Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
Lobby lounge

4. Residence Inn By Marriott Jacksonville - Mayo Clinic Area

Residence Inn By Marriott Jacksonville - Mayo Clinic Area
3.0 star property
Isle of Palms, 1.2 mi from Isle of Palms South
9.6 out of 10, Exceptional, (601 reviews)
"Great stay"
United States
Michaelanne
$144 nightly
The price is $164
Oct 18 - Oct 19
Total with taxes and fees
Residence Inn By Marriott Jacksonville - Mayo Clinic Area
Terrace/patio

5. TownePlace Suites by Marriott Jacksonville East

TownePlace Suites by Marriott Jacksonville East
3.0 star property
1.8 mi from Isle of Palms South
9.2 out of 10, Wonderful, (658 reviews)
"Great location close to the beach. Super well maintained facility. Everything was great!"
United States
gregory
$119 nightly
The price is $135
Oct 4 - Oct 5
Total with taxes and fees
TownePlace Suites by Marriott Jacksonville East
Breakfast, lunch and dinner served

6. Hilton Jacksonville at Mayo Clinic near Beaches

Hilton Jacksonville at Mayo Clinic near Beaches
4.5 star property
1.2 mi from Isle of Palms South
9.4 out of 10, Exceptional, (358 reviews)
"Excellent hotel and staff."
United States
Kristen
$177 nightly
The price is $201
Oct 17 - Oct 18
Total with taxes and fees
Hilton Jacksonville at Mayo Clinic near Beaches
Lobby

7. Margaritaville Jacksonville Beach

Margaritaville Jacksonville Beach
2.5 star property
Oceanfront, 3 mi from Isle of Palms South
9.0 out of 10, Wonderful, (4,500 reviews)
"Always a pleasure staying here"
United States
John
$169 nightly
The price is $192
Sep 22 - Sep 23
Total with taxes and fees
Margaritaville Jacksonville Beach
On the beach

8. Best Western Oceanfront

Best Western Oceanfront
3.0 star property
Oceanfront, 2.9 mi from Isle of Palms South
9.0 out of 10, Wonderful, (1,006 reviews)
"This is one of the best kept Best Western hotels I’ve ever been in. The hotel is walkable to the beach, dining, and activities. Parking is easy. The staff are very friendly and breakfast was varied for everyone’s needs."
United States
Sonya
$132 nightly
The price is $150
Sep 28 - Sep 29
Total with taxes and fees
Best Western Oceanfront
Exterior

9. Seahorse Oceanfront Inn

Seahorse Oceanfront Inn
2.5 star property
4.2 mi from Isle of Palms South
8.8 out of 10, Excellent, (800 reviews)
"Rooms very clean, property is well kept."
United States
Forrest
$118 nightly
The price is $134
Sep 29 - Sep 30
Total with taxes and fees
Seahorse Oceanfront Inn
Free daily continental breakfast

10. Fairfield Inn & Suites by Marriott Jacksonville Beach

Fairfield Inn & Suites by Marriott Jacksonville Beach
3.0 star property
Oceanfront, 3.2 mi from Isle of Palms South
8.6 out of 10, Excellent, (986 reviews)
"clean room nice beach location"
United States
Anne
$127 nightly
The price is $144
Oct 1 - Oct 2
Total with taxes and fees
Fairfield Inn & Suites by Marriott Jacksonville Beach
Exterior

11. Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area

Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area
2.5 star property
2.4 mi from Isle of Palms South
9.0 out of 10, Wonderful, (1,231 reviews)
"Just wish the hotel have a restaurant or a bar."
United States
Hollye
$118 nightly
The price is $134
Oct 11 - Oct 12
Total with taxes and fees
Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area
Outdoor pool, pool umbrellas, sun loungers

12. Four Points by Sheraton Jacksonville Beachfront

Four Points by Sheraton Jacksonville Beachfront
3.0 star property
Oceanfront, 2.8 mi from Isle of Palms South
9.0 out of 10, Wonderful, (1,005 reviews)
"Awesome stay"
United States
Susan
$178 nightly
The price is $202
Oct 4 - Oct 5
Total with taxes and fees
Four Points by Sheraton Jacksonville Beachfront
Standard Room, 2 Queen Beds, Accessible (Accessible Tub) | In-room safe, desk, laptop workspace, blackout drapes

13. Holiday Inn Express Jacksonville Beach by IHG

Holiday Inn Express Jacksonville Beach by IHG
3.0 star property
2.2 mi from Isle of Palms South
9.2 out of 10, Wonderful, (1,003 reviews)
"The staff was nice, and the breakfast was very good,"
United States
Jose
$118 nightly
The price is $134
Sep 27 - Sep 28
Total with taxes and fees
Holiday Inn Express Jacksonville Beach by IHG
Suite, 1 Bedroom, Ocean View | View from room

14. Courtyard by Marriott Jacksonville Beach Oceanfront

Courtyard by Marriott Jacksonville Beach Oceanfront
3.0 star property
Oceanfront, 3.2 mi from Isle of Palms South
8.4 out of 10, Very good, (1,001 reviews)
"Great hotel on the beach very good staff."
Canada
Marc
$165 nightly
The price is $187
Oct 1 - Oct 2
Total with taxes and fees
Courtyard by Marriott Jacksonville Beach Oceanfront
Property amenity

15. Element by Marriott Jacksonville Beach

Element by Marriott Jacksonville Beach
3.0 star property
Oceanfront, 2.7 mi from Isle of Palms South
9.6 out of 10, Exceptional, (587 reviews)
"Nice lodging a block from the beach. Great food nearby."
United States
Nick
$152 nightly
The price is $173
Oct 1 - Oct 2
Total with taxes and fees
Element by Marriott Jacksonville Beach
Desk, blackout drapes, iron/ironing board (on request), cribs (free)

16. Hyatt Studios Jacksonville/St Johns Town Center

Hyatt Studios Jacksonville/St Johns Town Center
2.5 star property
5.4 mi from Isle of Palms South
9.4 out of 10, Exceptional, (212 reviews)
"Very nice stay, they have grab and go breakfast as complimentary."
United States
Phi
$115 nightly
The price is $131
Oct 3 - Oct 4
Total with taxes and fees
Hyatt Studios Jacksonville/St Johns Town Center
Premium bedding, desk, iron/ironing board, cribs (free)

17. Holiday Inn Jacksonville E 295 Baymeadows by IHG

Holiday Inn Jacksonville E 295 Baymeadows by IHG
3.0 star property
6 mi from Isle of Palms South
8.6 out of 10, Excellent, (1,000 reviews)
"Great Hotel"
United States
Josh
$83 nightly
The price is $94
Oct 22 - Oct 23
Total with taxes and fees
Holiday Inn Jacksonville E 295 Baymeadows by IHG
Lobby

18. Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass

Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass
3.0 star property
5.5 mi from Isle of Palms South
9.2 out of 10, Wonderful, (1,001 reviews)
"Great in every way!! Very comfortable and clean and friendly"
United States
Joyce
$118 nightly
The price is $131
Oct 19 - Oct 20
Total with taxes and fees
Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass
Bar (on property)

19. Springhill Suites By Marriott Jacksonville Beach Oceanfront

Springhill Suites By Marriott Jacksonville Beach Oceanfront
4.0 star property
Oceanfront, 2.9 mi from Isle of Palms South
9.0 out of 10, Wonderful, (801 reviews)
"Beautiful room with a view. Great location and great restaurant on site!"
United States
Laura
$169 nightly
The price is $192
Oct 4 - Oct 5
Total with taxes and fees
Springhill Suites By Marriott Jacksonville Beach Oceanfront
Exterior

20. Casa Marina Hotel

Casa Marina Hotel
3.0 star property
Oceanfront, 3 mi from Isle of Palms South
8.4 out of 10, Very good, (1,000 reviews)
"Everything was good, personnel was nice an helpful the place is close to a nice area"
United States
Jimmy
$162 nightly
The price is $184
Sep 22 - Sep 23
Total with taxes and fees
Casa Marina Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in Isle of Palms South

Find the best Isle of Palms South areas and neighborhoods for the activities you enjoy most.
A city skyline with modern skyscrapers, a prominent Wells Fargo building, and a blue bridge over a river.
Photo by Ryan Ketterman
Open Photo by Ryan Ketterman

Downtown Jacksonville

Historic core with major corporations, Downtown Jacksonville offers diverse culinary and nightlife experiences at The Elbow. Explore attractions like Florida Theatre, TIAA Bank Field, and museums, while enjoying convenient transportation options.

A coastal cityscape at dusk with a prominent clock tower, waterfront, and historic buildings.

Amelia City

While visiting Amelia City, you might make a stop by sights like American Beach and Fernandina Beach.

A sunset over a beach with waves and a pier.

Oceanfront

If you're spending some time in Oceanfront, Oceanfront Park and Northeast Florida Beaches are top sights worth seeing.

A city skyline at night with illuminated buildings and a bridge reflecting on the water.

Southside

If you're spending some time in Southside, St. Johns Town Center and Orange Park Place Shopping Center are top sights worth seeing.

A golf course with a pond, trees, and buildings in the background.

Sawgrass

Visitors to Sawgrass like its beaches and riverfront, and Mickler Beach is a sight worth a stop.

Top Isle of Palms South Hotel Reviews

Margaritaville Jacksonville Beach

Margaritaville Jacksonville Beach

10/10 Excellent
"Great location with beautiful views, clean, beautiful rooms and lots to do around the area"
Keisha 1-night trip
Posted 4 hours ago
Margaritaville Jacksonville Beach

Frequently asked questions

What is Isle of Palms South like?
Travelers will be sure to find plenty to entertain them in Jacksonville Beach's Isle of Palms South neighborhood.
How many hotels will I be able to find in Isle of Palms South?
Expedia has 7 Isle of Palms South hotels and other accommodations, and one might make a good home base for venturing out into the greater Jacksonville Beach area.
If I need to cancel my hotel reservation in Isle of Palms South, will I receive a refund?
Yes, the majority of hotel room reservations are refundable provided that you cancel prior to the hotel's cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If your reservation is non-refundable, it may still be possible to cancel it and be given a refund within a 24-hour period of booking. Enter dates in and click on "Search", then use the "fully refundable" filter to view top deals in Isle of Palms South.
Where can I learn more about changing or cancelling my trip to Isle of Palms South?
To find more details about changing or cancelling your trip to Isle of Palms South, go to https://www.expedia.com/service/.
What are the top things to see and do in Isle of Palms South?
Cradle Creek Preserve, Windsor Parke Golf Club, and Jacksonville Beach Golf Club are just a few of the places to visit in and around Isle of Palms South. Windsor Commons Shopping Center and Harbor City Municipal Golf Course are also worth a visit when you're out sightseeing in Jacksonville Beach.

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